Immune responses to S. pneumoniae in chronic lung disease
Research type
Research Study
Full title
Investigating immune responses to Streptococcus pneumoniae in chronic lung disease
IRAS ID
215627
Contact name
Jeremy Brown
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Z6364106, data protection
Duration of Study in the UK
1 years, 11 months, 27 days
Research summary
Streptococcus pneumoniae causes substantial morbidity and over 3 million deaths globally each year. Additionally, it contributes significantly to the morbidity and mortality of individuals with chronic lung disease and the elderly. Host responses in humans to streptococcus pneumoniae are poorly described, and their contribution towards prevention or development of disease needs further investigation. We have developed a model that allows determination of multiple parameters of the acute inflammatory response and later immune response in humans following injection of killed bacteria into the skin. This has been characterized extensively following injection with the Gram-negative bacillus Escherichia coli, which has allowed determination of the spectrum of normal host responses as well as variations of relevance to various diseases. We now wish to apply this model and currently used laboratory techniques to investigate the effects of age and chronic lung disease on the early and late immune responses to S. pneumoniae in humans. We will use whole bacteria to establish the range of normal responses, and subsequently use mutant strains to demonstrate the roles of various bacterial protein factors for these responses.
REC name
London - Central Research Ethics Committee
REC reference
18/LO/0470
Date of REC Opinion
6 Aug 2018
REC opinion
Further Information Favourable Opinion