Immune Recovery in Autologous Transplant
Research type
Research Study
Full title
The impact of early immune recovery on long-term outcomes in autologous stem cell transplantation for Multiple Myeloma and Lymphoma
IRAS ID
265465
Contact name
Matthias Klammer
Contact email
Sponsor organisation
Joint Research and Enterprise Services
Clinicaltrials.gov Identifier
19/NS/0104, REC Reference Number
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
This study aims to investigate the role of early immune recovery following autologous stem cell transplant for Multiple Myeloma and Lymphoma. Autologous transplant involves transfusing a patient’s own, previously harvested peripheral blood stem cells following the administration of high-dose chemotherapy. Whilst the role of autologous transplant in allowing bone marrow regeneration following high-dose chemotherapy is well-described, there is some suggestion from recent research that a separate, immune-mediated mechanism may also contribute to its therapeutic effects. This study will address factors influencing early immune recovery and how these may relate to long-term outcomes.\nThe study will be carried out at St George’s Hospital in London and will comprise a prospective and a retrospective arm. In the prospective arm we will examine the stem cell product collected from patients to characterise its immune cell composition and relate this to early immune recovery and long-term outcome. We will also measure the recovery of immune cells in patient’s blood following transplantation and relate this to long-term clinical outcome. \nIn the retrospective arm, we will examine the stem cell product of patients who have undergone autologous transplant at St George’s in the last 2-3 years. This will involve defrosting a sample of their stored stem cell product for analysis of the immune cell content. Again, we will examine how this relates to early immune recovery and long-term clinical outcomes.\n
REC name
North of Scotland Research Ethics Committee 1
REC reference
19/NS/0104
Date of REC Opinion
25 Jun 2019
REC opinion
Further Information Favourable Opinion