Immune gene expression and tumour microenvironment in prostate cancer.

• Research type

  Research Study

• Full title

  How does radiotherapy affect immune gene expression and the tumour microenvironment in men with localised prostate cancer?

• IRAS ID

  178305

• Contact name

  Suneil Jain

• Contact email

  s.jain@qub.ac.uk

• Duration of Study in the UK

  2 years, 0 months, 1 days

• Research summary

  In patients undergoing either routine low dose rate brachytherapy (BT) or routine combination external beam radiotherapy (EBRT) and BT, needle access to the prostate gland is required for implantation of either radioactive seeds (in the case of BT) or fiducial markers (in the case of EBRT). During these procedures it is planned to take additional prostatic tissue samples for analysis of immune gene expression, lymphocytic infiltration and markers of hypoxia (HIF1α and GLUT1). This study purely surrounds the taking of these samples, all therapeutic procedures (BT or EBRT+BT) are happening exactly as standard of care.

• REC name

  HSC REC B

• REC reference

  16/NI/0013

• Date of REC Opinion

  9 Mar 2016

• REC opinion

  Further Information Favourable Opinion