Immune biomarkers and clinical outcome in trauma patients
Research type
Research Study
Full title
Prospective study on the associations between Immune biomarkers (including circulating cytokine profiles and T regulatory cell expression) and clinical outcome in patients after major trauma.
IRAS ID
172620
Contact name
Niroshini Nirmalan
Contact email
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
After major trauma, tissue injury results in a series of responses that are designed to promoted tissue repair. Both pro and anti inflammatory processes throughout the body occur;they are defined as the systemic inflammatory response syndrome (SIRS) and the counter regulatory anti-inflammatory response (CARS). Whilst these processes are essential to promote tissue repair, they can also result in harmful effects such as organ dysfunction - a leading cause for prolonged morbidity and mortality. It is our aim to identify the extent of SIRS and CARS in patients following admission to hospital with major traumatic injury. The inflammatory response will be evaluated by taking blood samples from the patients at intervals. Blood will be analysed for cell signalling proteins called cytokines and types of white blood cells called T regulatory cells. We will then identify the degree of pro and anti inflammatory response to the trauma and identify whether this is associated with clinically important outcomes, such as death and length of stay in the intensive care unit.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
15/NW/0262
Date of REC Opinion
17 Jun 2015
REC opinion
Further Information Favourable Opinion