Immediate vs conventional implant placement
Research type
Research Study
Full title
Influence of timing of implant placement on early healing molecular events: A two-centre, parallel group, pilot study
IRAS ID
322440
Contact name
Nikolaos Donos
Contact email
Sponsor organisation
Queen Mary University of London
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
NCT06276335, NCT number
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
The tooth extraction may be recommended by different reasons, including but not limited to severe tooth decay (cavities), tooth fracture, severe mobility and bone loss. A dental implant surgery is one of the treatment options used to replace a missing tooth. Different protocols for implant placement exist such as immediate implant placement when dental implant is placed immediately (IP) after tooth extraction or late implant placement when implants are placed after the gum and bone have healed following tooth extraction (DP). The aim of this clinical study is to describe the changes in the expression of biomarkers/molecules during the initial wound healing after different implant placement protocols: immediate implant placement (IP) or delayed/late implant placement (DP), and to illustrate the blood flow during the early healing phase following the above protocols.
There will be two treatment groups in this study - one group will receive an implant immediately after tooth extraction (IP) and the other group will receive the implant after soft and hard tissues have healed, as per study timeline.
This is a two-center prospective observational study with two parallel study groups and will consist of 10-11 visits approximately around a period of 16 months. The study will take place at the Centre for Oral Clinical Research (COCR), at the Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Royal London Dental Hospital - Barts Health NHS Trust (main centre), United Kingdom and at Clinic of Reconstructive Dentistry, University of Zurich, Zurich, Switzerland, in accordance with local guidelines and procedures/interventions detailed below.
REC name
London - Westminster Research Ethics Committee
REC reference
24/LO/0566
Date of REC Opinion
5 Aug 2024
REC opinion
Favourable Opinion