Imaging Features and Correlation with Genotype in CSC
Research type
Research Study
Full title
Imaging Features and Correlation with Genotype in Chronic Central Serous Chorioretinopathy
IRAS ID
287979
Contact name
Andrew Lotery
Contact email
Sponsor organisation
University Hospital Southampton, R&D Department
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Central Serous Chorioretinopathy (CSC), is a common cause of eye disease in the Western World amongst those of working age. It affects the retinal tissue in the back of the eye in an area known as the macula. There are two forms of CSC, acute and chronic. Acute CSC is the more prevalent form of the disease however, approximately 50% go on to develop chronic disease leading to a significant impairment of central vision. The cause of the disease is currently unknown and consequently, there are limited treatment options available. Furthermore, we are unable to determine which patients will go on to have chronic disease with loss of vision. Chronic CSC shows clinical similarities with age-related macular degeneration (AMD): a progressive chronic disease of the central retina. Genetic changes have been associated with both AMD and chronic CSC suggesting genetic and pathophysiologic overlap between these two conditions.
A recent NIHR funded randomized double-blind placebo-controlled trial (The VICI Study) in chronic CSC showed no benefit from a mineralocorticoid antagonist, eplerenone, a drug commonly used to treat heart failure. As part of this study a large database of images and biobank of DNA was collected.
In this study, we want to examine those images collected from the VICI study to look for imaging markers of chronic CSC and analyse the DNA collected for phenotype-genotype correlations.
We will analyse the optical coherence tomography (OCT), indocyanine green angiography (ICG), fundus fluorescein angiography (FFA), fundus autofluorescence (FA) and optical coherence tomography angiography (OCTA) images from CSC patients collected from the VICI study. Images will be compared to those from normal controls. The DNA of patients with CSC recruited from The VICI study will also be used to evaluate those genes that have previously been associated with CSC, and to look for relations between imaging features and genetic changes, enabling us to determine what changes might contribute to disease features.
Further examining the phenotype and genotype of CSC will provide new insights into the pathogenesis and disease course of this important retinal condition as well as furthering our understanding of related retinopathies such as AMD.REC name
East of England - Cambridge South Research Ethics Committee
REC reference
21/EE/0044
Date of REC Opinion
23 Mar 2021
REC opinion
Further Information Favourable Opinion