Image enhanced endoscopy in the Gastrointestinal Tract

• Research type

  Research Study

• Full title

  A series of prospective observational cohort studies investigating the clinical utility of image-enhanced endoscopy in the gastrointestinal (GI) tract

• IRAS ID

  259221

• Contact name

  Bu'Hussain Hayee

• Contact email

  b.hayee@.nhs.net

• Sponsor organisation

  King's College Hospital NHS Foundaiton Trust

• Duration of Study in the UK

  3 years, 0 months, 1 days

• Research summary

  Endoscopic procedures are performed on a daily basis in clinical practice. They involve the use of a flexible camera to look inside the gullet, stomach and bowel to diagnose abnormalities, take small tissue samples for analysis under a microscope (biopsy) and deliver treatments. Image-enhanced endoscopy (IEE) uses technology to enhance the video image during the procedure: altering magnification, colour, sharpness and brightness. This has the potential to improve diagnostic accuracy; potentially replace biopsies and can be integrated into computer-based diagnosis systems. At a time when demand for endoscopy is rising exponentially, generating a greater volume of biopsies for analysis; incurring financial costs and treatment delays. This is a single centre cohort study which will evaluate the accuracy of different IEE technologies across a range of conditions affecting the gastrointestinal system and potential to replace current investigations (e.g. biopsy). This includes but is not limited to inflammation of the gullet (reflux disease); inflammation of the stomach (atrophic gastritis); inflammation of the bowel (inflammatory bowel disease) and pre-cancerous changes. Potential participants include adults with capacity, required to undergo an endoscopic procedure as part of their routine care pathway. Participants will undergo a routine endoscopy; IEE images/video will be obtained by pressing a single button; which will be analysed and compared with routine investigations to determine diagnostic accuracy. Images will form the basis of a computer assisted diagnosis system. Most participants will only be included in the study from consent to the end of procedure (1 day), select participant groups will have follow-up consultations up to a year after the endoscopy, however, these consultations would have been performed as part of routine care outside of this study. This study does not deviate from the routine patient care pathway thereby minimising inconvenience caused to participants and ethical issues.

• REC name

  East Midlands - Derby Research Ethics Committee

• REC reference

  19/EM/0167

• Date of REC Opinion

  28 May 2019

• REC opinion

  Further Information Favourable Opinion