Illuminating the genetic impact on immune cell interactions - v1.0
Research type
Research Study
Full title
Elucidating genetic modulation of T cell - monocyte interactions and activation
IRAS ID
261865
Contact name
Rachel Kyd
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
Duration of Study in the UK
1 years, 0 months, 31 days
Research summary
The composition of cells in our bodies and different organs can vary between different people. The consequences of this variability may change how our immune system responds to infections or risk of different diseases, such as cancer or inflammatory diseases. We refer to this as cellular heterogeneity.
Cellular heterogeneity is a key feature of multicellular organisms and tissues compromised of mixtures of different cell types. The biological, environmental and developmental factors that influence this heterogeneity are largely unexplored. Further, the impact and consequences of differences in heterogeneity remain unknown. These include genetic, age, lifestyle and environmental factors.
We plan to study how heterogeneity in immune cells are altered by genetic, environmental and lifestyle factors, by studying healthy volunteers.
REC name
South Central - Berkshire Research Ethics Committee
REC reference
19/SC/0574
Date of REC Opinion
4 Nov 2019
REC opinion
Favourable Opinion