IL-10 Axis in paediatric IBD
Research type
Research Study
Full title
Gastrointestinal Mucosal IL-10 Axis in the Pathogenesis and Progression of Inflammatory Bowel Disease in Children
IRAS ID
143004
Contact name
Mona Bajaj-Elliott
Contact email
Sponsor organisation
UCL ICH
Research summary
Crohn’s disease, Ulcerative colitis, Indeterminate IBD and early-onset inflammatory bowel disease are collectively referred to as Inflammatory Bowel Disease (IBD). It is a chronic relapsing-remitting condition occurring in genetically susceptible individuals. The consensus is that IBD is a complex condition with multiple factors affecting its onset, progression and severity, the exact mechanisms of which are still poorly understood.
Gastrointestinal health is finely balanced between the intact gut immune system with gut microbiota. IL-10 is an anti-inflammatory cytokines which has an important role in maintaining gut health. Loss of IL-10 and IL-10 function results in colitis in mice and early-onset IBD in humans. Despite its importance, IL-10 regulation in human gut is still unknown.
Gut biopsies, blood, faecal and urine samples will be obtained with informed consent from children under the care of the Gastroenterology department at GOSH. These patients will be followed up prospectively and samples will be obtained at intervals depending on their clinical status.
Further insight in these areas, may result in biomarkers and novel therapies for children with IBD.
REC name
London - Central Research Ethics Committee
REC reference
14/LO/0364
Date of REC Opinion
28 Jun 2014
REC opinion
Further Information Favourable Opinion