iFR guided Coronary Artery Bypass Grafting (iCABG)
Research type
Research Study
Full title
Assessment of Graft Patency in Patients with Pre-Operative iFR measurements undergoing isolated first-time CABG
IRAS ID
265033
Contact name
Prakash P. Punjabi
Contact email
Sponsor organisation
Imperial College Healthcare NHS Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 10 months, 31 days
Research summary
BACKGROUND
Patients suffering from coronary artery disease undergo coronary artery bypass surgery (CABG) as standard care. The selection of which vessels to bypass is usually at the surgeon's discretion, forming an opinion based on the pre-operative angiographic imaging. Instantaneous free-wave ratio (iFR measurements) are more physiological to determine the severity of stenosis at the coronary arteries; however, it is currently not used for CABG pre-assessment, but only for percutaneous intervention and it has been shown to improve outcomes. By visual assessment what looks severe could have a normal iFR; similarly, by visual assessment what looks not severe could have an abnormal iFR. Currently, there is no course or agreement to follow the iFR level and this is only a decision to be made by a surgeon or institution, not preference. The aim of the study is to assess the graft patency at 12 months for patients undergoing standard off-pump CABG in whom incidentally iFR measurements have been taken. The patient will have a 3-month follow up (in person) and a 12-month follow up (telephone-based consultation). Before the 12-month follow up the patient will undergo a computed tomography coronary angiography (CTCA). Both at 3 and 12 months follow up assessments the patient will complete a pseudonymised Quality of Life (QoL) questionnaire. Although, the use of intracoronary physiology has not been extensively studied or validated in patients undergoing CABG.REC name
London - Harrow Research Ethics Committee
REC reference
22/PR/0019
Date of REC Opinion
11 Apr 2022
REC opinion
Further Information Favourable Opinion