iDx2
Research type
Research Study
Full title
Lung Health Checks: Integrated Biomarker Studies 2
IRAS ID
327590
Contact name
Peter Johnson
Contact email
Sponsor organisation
University Hospital Southampton NHS Foundation Trust
Duration of Study in the UK
5 years, 6 months, 29 days
Research summary
Screening for lung cancer is being carried out in the NHS using low-dose CT scans. This study will test whether adding a blood biomarker test to a routine low-dose CT scan can help identifying people with lung cancer. These biomarker tests can detect abnormal proteins or molecules secreted by a tumour or a specific response of the body to the presence of cancer and are hoped to improve the early diagnosis of lung cancer, and thereby survival, in the future.
People undergoing a routine NHS Lung Cancer Screening (LCS), formerly known as a Targeted Lung Health Check, across the UK will be approached by a member of the clinical team, or an appropriately trained member of the research team, and asked if they are willing to participate in this study. If participants consent to the study, they will donate up to 50mL of blood. The blood taken will be sent to laboratories abroad for analysis of various biomarkers, including circulating tumour DNA and abnormal proteins.
No additional visits for the study will be required. Following the LCS visit, demographic and clinical data will be collected from the participants NHS health records and NHS Digital. Permission will be sought to enable surplus samples to be stored for future approved translational research studies.
REC name
London - Bloomsbury Research Ethics Committee
REC reference
25/PR/0474
Date of REC Opinion
29 May 2025
REC opinion
Further Information Favourable Opinion