Identifying new biomarkers of Parkinson's from routine brain imaging
Research type
Research Study
Full title
Identifying new biomarkers of Parkinson's from routine brain imaging
IRAS ID
280243
Contact name
Stephen Mullin
Contact email
Sponsor organisation
University of Plymouth
Clinicaltrials.gov Identifier
PEN/006/000/A, NIHR NTN funding number
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
We seek permission to use routine computer tomography (CT), magnetic resonance spectroscopy (MRI) and nuclear medicine (NM) brain imaging data to produce new diagnostic tests for the onset of Parkinson's disease. This will enable earlier diagnosis than is currently possible. This will entail the analysis of CT/MRI/NM brain images collected prior to the point when these subjects were diagnosed with PD. These images will be anonymised, however will be used without the express consent of these subjects.
Briefly, PD cases will be identified from routine clinical databases, hospital electronic records and GP records. Data held on existing research and clinical databases related to the clinical features and progression of these subjects will be appended to these records. CT/MRI/NM scans will be matched using pseudoanonymised identifiers (NHS number, year of birth, first two letters of postcode) by a member of the routine clinical care team who is not part of the research team. A number of matched control CT/MRI/NM scans will also be obtained as a control group. Once matched, the complete dataset will be anonymised for analysis, with clinically relevant details (such as scanner used, date of scan, indication for scan and report of scan) included within the dataset.
REC name
London - Westminster Research Ethics Committee
REC reference
21/PR/0918
Date of REC Opinion
8 Jul 2021
REC opinion
Favourable Opinion