Identifying dysplasia and cancer using lectins Pilot Study
Research type
Research Study
Full title
Investigating the use of fluorescent lectins to identify dysplasia and cancer during endoscopy and surgery
IRAS ID
155198
Contact name
Trevor Yeung
Contact email
Sponsor organisation
Joint Research Office
Research summary
The main aim of this project is to assess whether the application of labelled lectins can help identify abnormal tissue during endoscopy and surgery, compared to white light. Lectins are proteins that are derived from plants and bind to specific types of tissue. Labelled lectin will shine brightly (fluoresce) when viewed under certain colours of light. This signal can be detected by special cameras built into colonoscopes.\n\nThis will be a pilot and feasibility study. We wish to compare the ability of lectins with white light to identify abnormal and cancer tissue during endoscopy and surgery. We would like to recruit a total of 50 patients. 30 will undergo endoscopy (colonoscopy or flexible sigmoidoscopy). 20 will undergo transanal endoscopic microsurgery (TEMS),including robotically assisted procedures.\n\nThe potential benefit of this procedure is that we may be able to identify abnormal areas of tissue more easily with this technique.\n\nFunding source: University of Oxford, Nuffield Department of Surgery and BDRF\nRecruitment sites: Oxford University Hospitals NHS Trust\n\n\n\n
REC name
South Central - Oxford B Research Ethics Committee
REC reference
14/SC/1250
Date of REC Opinion
1 Jul 2015
REC opinion
Further Information Favourable Opinion