Identifying an environmental factor for Crohn's disease
Research type
Research Study
Full title
Identifying an environmental factor for Crohn's disease
IRAS ID
194777
Contact name
Arthur Kaser
Contact email
Sponsor organisation
R&D Manager CPFT
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
Crohn’s disease (CD), a form of inflammatory bowel disease, affects one in a thousand individuals in the western world. Genome wide association studies have identified a number of genetic markers (polymorphisms) that confer increased risk of developing this disease. However environmental factors that trigger disease in the genetic susceptible are largely unknown. Previous studies have demonstrated that patients with a diverting or loop terminal ileostomy experience downstream recurrence of disease with infusion of intestinal luminal contents. This suggests that CD may be triggered by agents in the faecal stream. This study proposes to study ileal and colonic effluent from CD patients with defunctioned ileostomies or colostomies in model reductionistic systems. The ileal and colonic effluent will also be analysed to determine if extracts of the various constituents alone are sufficient to trigger disease.
REC name
London - Stanmore Research Ethics Committee
REC reference
16/LO/1079
Date of REC Opinion
10 Jun 2016
REC opinion
Favourable Opinion