Identification of novel MRI features in brain tumours - a pilot study
Research type
Research Study
Full title
Identification of novel imaging features in brain tumours using non-invasive advanced MRI – a pilot study
IRAS ID
210819
Contact name
Sotirios Bisdas
Contact email
Sponsor organisation
University Colllege London Hospitals NHS Foundation Trust
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
Current evidence indicates an important diagnostic and predictive value for imaging and histopathological biomarkers in patients with gliomas. However, there are still unanswered questions on the role of advanced imaging in gliomas management.
In the light of new advances in histopathological tumour classification, which takes into account molecular features of the gliomas, it is now evident that conventional imaging cannot elucidate tumour function and investigate the constitutional mechanisms of the brain tumours. These facts have hindered the discovery of clinically robust imaging biomarkers. Pathophysiological, histological and molecular heterogeneity of low and high grade gliomas have aggravated this shortcoming of imaging.
Therefore, novel biomarkers that improve the phenotyping and provide reliable and responsive outcome measure and indicate new therapy targets are desperately needed.
Unselected patients presenting with glial brain tumours will be imaged using a comprehensive multimodality MR imaging protocol that will include high-resolution structural imaging, physiological imaging, novel metabolic imaging techniques and elaborated post-processing. We aim to extract out of the patients’ imaging signatures by means of computational methods novel biomarkers. These biomarkers will be used to enhance the diagnostic and prognostic value of imaging in all patients with gliomas.REC name
London - Stanmore Research Ethics Committee
REC reference
16/LO/2081
Date of REC Opinion
11 Jan 2017
REC opinion
Further Information Favourable Opinion