Identification of novel biomarkers for early detection of lung cancer
Research type
Research Study
Full title
Biomarkers that identify lung nodules with a malignant propensity
IRAS ID
273139
Contact name
Simon Hart
Contact email
Sponsor organisation
University of Hull
Duration of Study in the UK
10 years, 0 months, 1 days
Research summary
We want to identify and characterise proteins in blood samples that can act as biomarkers to enable the early diagnosis of lung cancer.
Patients with incidental lung nodules are often detected on CT scans and these patients undergo prolonged monitoring and repeat imaging to detect the approximately 5% who progress to lung cancer. Our study will focus on patients with high risk incidental lung nodules, lung cancer (that has developed from lung nodules), de novo lung cancer, inflammatory lung disease and healthy donors.
Blood (serum) and urine samples will be collected, ideally when samples are being taken for routine clinical care. Surplus archived tissues samples will be analysed from patients who have undergone surgical resection, with healthy adjacent lung tissue and patients not found to have lung cancer acting as additional controls.
Proteins we detect will be examined for their sensitivity and specificity as biomarkers for early lung cancer.REC name
London - Riverside Research Ethics Committee
REC reference
21/LO/0158
Date of REC Opinion
4 Feb 2021
REC opinion
Favourable Opinion