Identification of high-risk plaques using CT-based PlaqueMaps
Research type
Research Study
Full title
Identification of high-risk atherosclerotic plaques through coronary CT: an observational cohort study
IRAS ID
156903
Contact name
Deepa Gopalan
Contact email
Sponsor organisation
Papworth Hospital NHS Trust
Clinicaltrials.gov Identifier
07/H0307/90, Previous REC Reference
Duration of Study in the UK
0 years, 3 months, 0 days
Research summary
Cardiovascular disease remains the leading cause of death worldwide. Identifying individual patients at risk of a future adverse events, including myocardial infarctions (heart attacks), remains a major diagnostic challenge. Recent studies have shown that coronary plaques responsible for heart attacks are composed of a large lipid core with a thin overlying fibrous cap. Although these features can be identified using invasive imaging modalities, non-invasive imaging options remain limited due to their poor spatial resolution. Recently, we have developed and validated a novel tool that will allow us to characterise coronary plaque composition based on dual source CT images. Our aim is to assess this tool within a cohort of patients who have already undergone a coronary CT as part of a previous study.
REC name
London - Queen Square Research Ethics Committee
REC reference
14/LO/2130
Date of REC Opinion
27 Nov 2014
REC opinion
Favourable Opinion