Identification of biomarkers associated with renal obstruction
Research type
Research Study
Full title
Proteomic identification of novel biomarkers for early diagnosis of renal sufferance in obstructed kidneys
IRAS ID
164792
Contact name
Elizabeth Bruna
Contact email
Sponsor organisation
Guy's and St Thomas' NHS Foundation Trust
Duration of Study in the UK
2 years, 2 months, 1 days
Research summary
Renal obstruction cause progressive damage and loss of renal function.
The classic diagnostic approach includes radiological investigations like ultrasound scan, fluoroscopy and nuclear medicine tests and the indication for surgery is based on worsening of renal dilatation in serial ultrasound scans or identification of a reduced renal function associated with obstructed or delayed drainage.
Proteomic is a new discipline that has developed in the last decades and has became an important tool in various fields such as cardiovascular diseases. It consists in an analysis or the proteins identified into the urine (and serum) as a consequence of organ damage.
We aim to use proteomic to investigate children affected by unilateral renal obstruction in order to identify urinary markers of early renal damage. Once identified, the markers will be used to detect early renal sufferance in children with renal obstruction. This will provide a new and innovative tool that can be used for assessing the children with diagnosed or suspected renal obstruction in order to identify those who require surgical correction of the obstruction at the possible earliest time point (before the permanent damage is established).REC name
London - Camberwell St Giles Research Ethics Committee
REC reference
19/LO/1659
Date of REC Opinion
10 Dec 2019
REC opinion
Further Information Favourable Opinion