ID-AF
Research type
Research Study
Full title
Comparison of the performance of Implantable Cardiac Monitors and Cardiac Implantable Electronic Devices in detecting Atrial Fibrillation (ID-AF)
IRAS ID
268739
Contact name
Timothy Betts
Contact email
Sponsor organisation
Oxford University Hospital NHS foundation Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Atrial fibrillation (AF) is the most common abnormal heart rhythm disturbance, affecting 1-2 million people in the UK. The irregular heartbeat caused by AF can make the heart pump blood less efficiently. As a result, AF significantly increases the risk of having a stroke, heart failure and dementia. However, a significantly proportion of people have no symptoms, and they may be only found to be in AF after having a stroke. Therefore, diagnosis largely relies on accurate ECG monitoring.
AF episodes can be unpredictable and easily missed unless continuous ECG monitoring is undertaken. Pacemakers can continuously record the heart’s electrical activity and detect AF with a high degree of confidence. However, they are invasive and rely on electrical wires implanted inside the heart, and hence less suited to be used as primary monitoring devices. To overcome these difficulties, implantable cardiac monitors (ICM) have been designed to be placed under the skin.
The new generation of ICMs can now be injected under the skin. Moreover, they connect with the patient’s smartphone and transmit recordings. Despite these significant improvements, their ability to reliably capture AF has never been tested against pacemakers.
The aim of this project is to study the performance of the two commonly used ICMs in detecting AF episodes and explore how the new connectivity can empower patients and improve patient care. We plan to inject an ICM in 30 patients with AF and pre-existing pacemaker. After a period of 6 months, we will compare how many episodes were detected in each device. With the information collected we will try to understand the pitfalls in the current technology and develop strategies to improve it.
Accurate, minimally invasive long-term ECG monitor can have far reaching benefits for patients, both in routine clinical practice and research.
REC name
London - Stanmore Research Ethics Committee
REC reference
21/LO/0508
Date of REC Opinion
13 Jul 2021
REC opinion
Favourable Opinion