ICECAP Inflammation and fibrosis: Causes in adhEsive CAPsulitis
Research type
Research Study
Full title
Inflammation and fibrosis: causes in adhesive capsulitis (ICECAP)
IRAS ID
247757
Contact name
Jonathan Rees
Contact email
Sponsor organisation
University of Oxford Clinical Trials & Research Governance
Duration of Study in the UK
4 years, 0 months, 17 days
Research summary
Musculoskeletal diseases including those affecting the shoulder are a common and significant global disease burden in our ageing population. Diseases of the shoulder including adhesive capsulitis are often characterized by pain and progressive shoulder immobility. Adhesive capsulitis, or Frozen Shoulder as it is commonly known, is often very disabling, impeding activities of daily living and frequently prevents the maintenance of a fit and healthy lifestyle. The symptoms associated with the disease usually resolve over time leading to functional recovery, however the duration of the symptoms may be two years or more. Furthermore, a significant proportion of patients have ongoing symptoms in the long term.
Inflammation and fibrosis is known to contribute to the development of the disease but the precise mechanisms are not fully understood. The focus of this project is to improve understanding of the underlying biological processes, an improved understanding of the biological basis behind fibrosis and inflammation will provide insights into new treatment strategies for symptomatic patients. The findings from this research will be translated to advance therapeutic approaches to target fibrosis and inflammation in patients with other common musculoskeletal diseases.Specifically, we aim to identify and characterize the distinct populations of immune and stromal cells present in both normal and chronically inflamed diseased capsular tissue and, importantly, determine how the presence of immune cells influence resident fibroblast cells in shoulder tissues to improve our understanding of the type of inflammation present in adhesive capsulitis. The project will involve collection of capsular tissue from patients undergoing planned shoulder procedures as part of their routine clinical care pathway. This tissue will then be studied using cutting edge laboratory techniques.
REC name
South Central - Oxford B Research Ethics Committee
REC reference
18/SC/0649
Date of REC Opinion
27 Nov 2018
REC opinion
Favourable Opinion