ICAF - BETA

• Research type

  Research Study

• Full title

  Improving cardiac function in high-risk surgical patients: exercise testing, biomarkers and beta-blockade

• IRAS ID

  226432

• Contact name

  Jonathan Wilson

• Contact email

  Jonathan.rjt.wilson@york.nhs.uk

• Sponsor organisation

  York Teaching Hospitals NHS Foundation Trust

• Eudract number

  2017-002443-15

• Duration of Study in the UK

  2 years, 4 months, 31 days

• Research summary

  Major elective abdominal surgery carries a significant risk of mortality and morbidity, a proportion of which is directly due to specific cardiac disease, particularly heart failure. Before people have major surgery they undergo a simple test on a cycle machine, which helps to determine if there are likely to be any particular problems during or after the surgery. These results are used to plan the best way to look after patients around the time of their operation as part of their standard care.
  
  For a small number of patients the cycle exercise test shows that the heart function is not as good as expected, with these patients showing a higher risk of developing serious problems after surgery.

  The purpose of this particular study is to see if the heart function in surgical patients can be improved by the prescription of medication which is effective in improving heart function, thus reducing the risk of mortality and morbidity for these patients.

  This is a single centre study taking place at York Teaching Hospital NHS Foundation Trust

  Patients aged 55 years or over, scheduled for major abdominal surgery will be eligible. These patients will be sent information about the study prior to their routine pre-assessment appointment. Those patients who consent will undergo screening as part of their appointment; if they meet all inclusion criteria they will be enrolled and prescribed Bisoprolol to be taken daily. After 10 days a follow up appointment will be required to review heart function.

• REC name

  Yorkshire & The Humber - Leeds West Research Ethics Committee

• REC reference

  17/YH/0222

• Date of REC Opinion

  25 Aug 2017

• REC opinion

  Further Information Favourable Opinion