IBM Renal
Research type
Research Study
Full title
Investigation of differential biology of benign and malignant renal masses using advanced magnetic resonance imaging techniques
IRAS ID
314155
Contact name
Ferdia Gallagher
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and University of Cambridge
Duration of Study in the UK
2 years, 6 months, 31 days
Research summary
This study will be separated into three different imaging techniques called Hyperpolarised MRI, Sodium MRI and Deuterium Metabolic Imaging (DMI) MRI. Up to 30 participants (up to 10 participants in each imaging technique) will be recruited to this study with either a suspected or confirmed benign renal mass(es) or a suspected malignant renal mass(es). These will be equally distributed across the imaging techniques. The aim is to determine whether these imaging techniques can identify differences between benign and malignant renal masses with the ultimate aim of reducing unnecessary surgery and/or treatments for those patients that have benign masses.
Where possible, the imaging data will be compared and correlated to metabolic activity within samples of the renal mass(es). This is an optional part of the study and declining to take part in this will not impact participation in the rest of the study. These research samples will be taken at the same time as clinically required biopsy procedures (e.g. during surgery or at biopsy procedure). The aim of this would be to determine if the imaging techniques can identify different areas of the renal mass and normal surrounding tissue.
Participants will be asked if they are willing to take part in an optional repeat scan within seven days of their first scan. This will be a duplication of the first scan and will be used to provide information on how repeatable these novel imaging techniques are.
For those participants that are not asked to take part in the repeat scan, they will be asked if they are willing to take part in an optional scan using one of the other imaging techniques within 14 days of their first scan. The aim of this will be to determine whether multiple imaging techniques can provide complementary information to better understand renal masses.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
22/EE/0136
Date of REC Opinion
31 Aug 2022
REC opinion
Further Information Favourable Opinion