Hypoxia driven genomic instability in-situ

• Research type

  Research Study

• Full title

  Hypoxia driven genomic instability in-situ

• IRAS ID

  315257

• Contact name

  Robert Bristow

• Contact email

  robert.bristow@manchester.ac.uk

• Sponsor organisation

  The University of Manchester

• Clinicaltrials.gov Identifier

  22_HTS08_03, MCRC Biobank Reference

• Duration of Study in the UK

  4 years, 8 months, 30 days

• Research summary

  Low oxygen (hypoxia) in tumours leads to worse patient response and survival. We are aiming to investigate how this might occur. Previous studies in multiple tumour types have linked hypoxia with increasing genetic alterations. We will be using a novel technology to look at the relationship between areas of hypoxia and genetic alterations in those regions.

• REC name

  North West - Greater Manchester Central Research Ethics Committee

• REC reference

  22/NW/0286

• Date of REC Opinion

  30 Aug 2022

• REC opinion

  Favourable Opinion