Hydrogen sulphide production in children and neonates
Research type
Research Study
Full title
Measuring exhaled hydrogen sulphide in ventilated children and neonates with minor conditions (normal), following major surgery and those who are septic.
IRAS ID
215983
Contact name
Andy Petros
Contact email
Sponsor organisation
Great Ormond Street Hospital
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
We have recently demonstrated that hydrogen sulphide (H2S) gas can be detected in the exhaled breath of children and neonates. Furthermore we have seen a significant increase in production in both groups who are septic. Our origin hypothesis that H2S production increases in sepsis and can be detected in exhaled breath was correct. Our original pilot study demonstrated a significant difference between septic children and controls and although adequately powered only included twenty heterogenous septic and twenty control patients. We now need to confirm this observation with a larger sample size and in more clinical conditions to better describe this novel observation. Peer review of our manuscript submission asked if we had studied children who were not septic but had an inflammatory process such as following major surgery, those who had viral illnesses and those with sepsis of respiratory origin. We wish to include these groups in our new application. We would like to enrole 150 patents, 30 each in 5 groups.\nWe will use the same protocol as our pilot study.
REC name
London - Bloomsbury Research Ethics Committee
REC reference
17/LO/1842
Date of REC Opinion
8 Dec 2017
REC opinion
Further Information Favourable Opinion