HYDRA OCT
Research type
Research Study
Full title
Combined Coaxial Optical Coherence Tomography system to image the retina and choroidal structures and estimate tissue reflectivity in the diseased retina.
IRAS ID
243713
Contact name
Adnan Tufail
Contact email
Sponsor organisation
Moorfields Eye Hospital NHS Foundation Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
0 years, 6 months, 1 days
Research summary
Detailed examination under a microscope of the light sensitive layers of the eye (retina) in conditions such as age-related macular degeneration (the commonest cause of blindness in the UK) have noted a build-up abnormal deposits in or under the retina. Being able to detect subtle abnormal deposits at an early stage is crucial for better understanding and monitoring of many potentially blinding conditions.
This study aims to evaluate a modified commercially available eye scanner (an Optical Coherence Tomography (OCT) device) that is available in most eye hospitals and many high street opticians that non-invasively generates a 3D picture of the layers of the retina in a few seconds. The study compares the modified OCT with the standard OCT to see if it can give us more insight into disorders of the retina. The modification is to a Spectralis® OCT-system by adding a second light source of a different longer wavelength. Other commercially available OCT scanners already use this longer wavelength of light to allow for visualisation of deep structures under the retina but at the expense of seeing less superficial detail. Combining both wavelengths of light in the scanner and using them simultaneously could have the advantage of allowing optimum visualisation of inner and subretinal structures and well as giving us insights as to the nature of any abnormal deposits.
The ability of the standard and modified OCT to acquire repeatable and good quality images of retina and adjacent structures and identify tissue layers will be compared. In addition analysis of how the two light sources in the modified device reflects off tissue deposits differently will be analysed to see if this gives us insight into the content of the deposit in the retina.REC name
London - City & East Research Ethics Committee
REC reference
19/LO/0042
Date of REC Opinion
14 Feb 2019
REC opinion
Further Information Favourable Opinion