Human vasodilatory response of GLP-1
Research type
Research Study
Full title
Haemodynamic effects of GLP-1 in the forearm and during elective PCI in humans
IRAS ID
125985
Contact name
Stephen P Hoole
Contact email
Sponsor organisation
Papworth Hospital NHS Foundation Trust
Research summary
GLP-1 is a naturally occuring peptide hormone secreted by cells in the gut in response to food. GLP-1 has the potential to protect the heart against the damage that is caused during a heart attack. One way it could do this is to dilate the blood vessels and improve blood supply to the affected area of the heart. In this study, we are looking to see how GLP-1 can dilate blood vessels in humans, in both peripheral arteries and coronary arteries. This information will help to determine whether vasodilation or haemodynamic effects contribute to the potential cardioprotective effects of GLP-1 against ischaemic damage.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
14/EE/0018
Date of REC Opinion
1 Jul 2014
REC opinion
Further Information Favourable Opinion