Human IBD Enteroid Study(MINIGUT)
Research type
Research Study
Full title
Modelling Intestinal iNflammation and predIctinG response to therapies Using human enTeroids
IRAS ID
220345
Contact name
Paloma Ordonez Moran
Contact email
Sponsor organisation
University of Nottingham
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Inflammatory Bowel Diseases (IBD) is made up predominantly of Crohn’s disease (CD) and Ulcerative Colitis (UC). There is no specific known cause for these conditions but it is thought to be a combination of one’s inherited DNA, the bacteria in the bowel and the immune system. In the recent past we are seeing more bowel infections in patients with IBD specifically with a bug called Clostridium Difficile (CDI). We do not know why CDI happens but CDI can badly affect the outcome of IBD patients, not uncommonly leading to surgery. We are unsure how to treat these conditions and what specific treatment each patient would need. A better understanding of these conditions and how the medications that are used to treat them, actually work is needed.
Unfortunately, most initial scientific studies are undertaken in animals. Although these are useful, they do not exactly replicate human nature.
What would be very useful would be to be able to study human disease in humans but without putting humans at risk. This is exactly what this study is aiming to do.
We aim to recruit patients with active IBD and/or CDI prior to their scheduled standard-of-care NHS endoscopy and seek permission to take extra bowel biopsies and a stool sample for research purposes. We will use these biopsies to extract stem cells. These cells will then be used to re-grow a miniature version of the bowel in our laboratory. This will allow us to study these conditions in a safe laboratory environment. The final aim of this study is that in the future this method might allow us to get to know exactly why IBD and/or CDI happen and work out what the best treatment options are.REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
17/EM/0126
Date of REC Opinion
16 May 2017
REC opinion
Further Information Favourable Opinion