Host-microbiota interaction in inflammatory disease
Research type
Research Study
Full title
Role of host-microbiota interaction in the pathogenesis of inflammatory disease and liver disease
IRAS ID
117320
Contact name
Tariq Iqbal
Contact email
Sponsor organisation
University Hospital Birmingham
Duration of Study in the UK
2 years, 10 months, 5 days
Research summary
Ulcerative colitis (UC) is a chronic, debilitating relapsing form of inflammatory bowel disease and its incidence is rapidly increasing in the United Kingdom. Patients with UC are at risk of primary sclerosing cholangitis (PSC), a chronic cholestatic liver disease with significant morbidity and mortality and no effective pharmacotherapy. Recent findings indicate that the bacteria in the bowel may play an important role in the pathogenesis of UC and PSC. However the, its exact role has still to be elucidated.
The overall goal of this study is therefore to understand the role of bacteria in the gut in the chronic inflammatory conditions specifically inflammatory bowel disease and primary sclerosing cholangitis and to determine its role as a potential target for therapy. I plan to investigate the functional differences in gut microbiota and its interactions with mucosal immune system and gut permeability.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
17/WM/0385
Date of REC Opinion
22 Jan 2018
REC opinion
Further Information Favourable Opinion