Hospital acquisition of resistant enteric organisms
Research type
Research Study
Full title
Microbiology and epidemiology of multi drug resistant enteric organisms among hospital patients and association with antibiotic use, a prospective observational study
IRAS ID
238352
Contact name
Sarah Lou Bailey
Contact email
Sponsor organisation
Guy's and St Thomas' Foundation NHS Trust
Duration of Study in the UK
0 years, 6 months, 27 days
Research summary
Antimicrobial resistance has been accepted as the next grand challenge for global society. It has been estimated that by 2050, 10 million lives a year and a cumulative 100 trillion USD of economic output are at risk due to the rise of resistant infections.\n\nIn the past much emphasis around drug resistance and antimicrobial stewardship has been placed on MRSA, leading to enhanced hospital screening surveillance and new treatment options. However, the threat of multi drug resistant enteric organisms (MDR-E) has not led to a similar response.\n\nUntil now, the major focus to contain and avert resistance transmission has been limited to the discovery of carriage through an infection during an inpatient hospital stay. A significant additional and largely un-quantified threat is spread of resistant organisms from colonised individuals from the community who are admitted into hospitals.\n\nFrom our own recently conducted research, the prevalence of MDR-E colonisation has been found to be 9.0% among new admissions to our hospital, but no data exist from our setting or elsewhere to determine the subsequent rate of acquisition of MDR-E, or to explore its potential association with use of antimicrobial therapy. We know from previous published research that infection with MDR-E is responsible for longer hospitalizations and poorer outcomes.\n\nTherefore, we plan to explore acquisition of MDR-E in patients admitted to a large London teaching hospital and determine its association with use of antibiotic therapy. A rectal swab will be collected from participants at the time of admission to hospital and again prior to discharge. Participants will be asked a simple questionnaire to establish risk factors, and clinical records will be reviewed to determine antibiotic use. Samples will be tested for the presence of MDR-E. Acquisition of MDR-E, its association with antibiotic use, and any other clinically relevant associations will be reported.
REC name
South Central - Oxford A Research Ethics Committee
REC reference
18/SC/0100
Date of REC Opinion
20 Feb 2018
REC opinion
Favourable Opinion