Hormonal values post GnRH agonist trigger for IVF (v1)
Research type
Research Study
Full title
Relevance of hormonal values 12 hours following GnRH agonist trigger for IVF parameters.
IRAS ID
253648
Contact name
Roy Homburg
Contact email
Sponsor organisation
Homerton University Hospital NHS Foundation Trust
Duration of Study in the UK
0 years, 9 months, 31 days
Research summary
This study involves measuring blood hormone levels 12 hours after the last, so-called trigger, injection to cause ovulation in an IVF cycle.
The routinely used trigger is hCG but in rare cases this may be responsible for the severe complication of ovarian hyperstimulation syndrome (OHSS). To avoid this complication in susceptible cases a different more gentle trigger called agonist is now used to produce mature eggs instead of hCG.
The measurement of hormone levels (particularly luteinising hormone, LH), 12 hours after the injection of the agonist trigger will help us to determine their optimal level at which the ideal number of mature eggs are produced.
Below this optimal level the chances of producing mature eggs needed for fertilization are slim. With agonist trigger the aim would be to get a maximum yield of mature eggs, giving rise to good quality embryos that could be frozen for replacement in future cycles.
Presently, the dose of agonist used is standard but arbitrary.
This research, involving the taking of one blood sample, 12 hours after the trigger injection, will help us determine the dose of agonist trigger that is individually required to produce the desirable hormone levels at 12 hours after the trigger and consequently the best outcome of the IVF cycle.REC name
London - Central Research Ethics Committee
REC reference
18/LO/1825
Date of REC Opinion
6 Dec 2018
REC opinion
Further Information Favourable Opinion