Horizontal cell function
Research type
Research Study
Full title
Horizontal Cell Function: A Study of Patients with Geographic Atrophy
IRAS ID
337860
Contact name
Matteo Rizzi Bringoli
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Z6364106/2024/02/46 health research , UCL Data Protection Reference no.
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Macular degeneration remains the leading cause of blindness in the developed world, and there are to date no treatments to reverse its effects on vision. Patients who lose central vision rely on eccentric fixation to perform visual tasks including recognizing faces and reading. We have recently discovered that this central lesion affects remaining vision outside of the scotoma.
The study focuses on lateral interaction in the human retina, particularly those mediated by cells called Horizontal cells. Its purpose is to understand the extent to which these lateral interactions shapes shapes our vision. The study will involve participants with normal vision as well as patients with macular degeneration, all of adult age. The result of the study are expected to reveal the extent to which lateral interactions affect vision in the surviving retina of patients with forms of macular degeneration.
REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
24/NE/0124
Date of REC Opinion
5 Jul 2024
REC opinion
Further Information Favourable Opinion