Home Oral Glucose Tolerance Test
Research type
Research Study
Full title
The use of a Self-Administered Electronic Oral Glucose Tolerance Test kit in screening for Cystic Fibrosis Related Diabetes in children with Cystic Fibrosis
IRAS ID
164960
Contact name
Catherine Peters
Contact email
Sponsor organisation
University College London
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Cystic Fibrosis related diabetes (CFRD) is the most common secondary complication of Cystic Fibrosis(CF). It affects nearly 20% of adolescents and 40-50% of adults. Undiagnosed CFRD is associated with significant decline in lung function and nutritional status with an increase in mortality. This emphasises the importance of screening for CFRD in children with CF to minimise the nutritional and pulmonary consequences of diabetes.
The current gold standard screening tool, the Oral Glucose Tolerance Test (OGTT), is resource intensive and the requirements placed on the patient and their parents/guardians by it lead to poor uptake of the procedure.
The standard OGTT requires an individual/child and a parent to attend a clinical facility while fasted and requires trained health care professionals to take venous samples, analyse and interpret the results. There are also problems encountered in standardising the test. The patient should be fasted and must travel to clinic for the test in the morning. The OGTT, if done at hospital, can therefore affect an individual’s time off work, time off school, can cause inconvenience and expensive for a parent/guardian and child to travel to clinic. The unpredictability of workload for hospital staff means that test times are often not strictly adhered to or accurately recorded. In patients with cystic fibrosis there is also an additional risk of cross infection when they attend the hospital for OGTT. These factors limit the uptake of OGTTs for screening in children with cystic fibrosis.
To overcome these issues a simple, disposable, self-administered electronic OGTT Kit containing everything required to perform the OGTT at home has been used in this study.
The aim of this study is to establish if the self-administered electronic Oral Glucose Tolerance Test kit can increase the annual uptake of screening for CFRD in children who are between 10 and 17 years of age with CF.REC name
London - Harrow Research Ethics Committee
REC reference
15/LO/0778
Date of REC Opinion
7 Jul 2015
REC opinion
Further Information Favourable Opinion