Histological Features in Testicular Cancers – Effect on Prognosis
Research type
Research Study
Full title
Detailed Histological Features in Testicular Germ Cell Tumours (Not Currently Routinely Reported) – Effect on Prognosis
IRAS ID
152979
Contact name
Clare L Verrill
Contact email
Sponsor organisation
Oxford University Hospitals NHS Foundation Trust
Duration of Study in the UK
10 years, 0 months, 1 days
Research summary
Testicular cancers are mostly of germ cell type. There are some established risk factors that can be seen microscopically and included in pathology reports e.g. vascular invasion. But there are factors that we are not yet aware of and are not routinely reported e.g. tissue death (necrosis) and the impact of these on prognosis (disease recurrence, distant tumour spread or death) has not yet been evaluated. It is possible either to evaluate these by a pathologist examining these features down a microscope or using a computer to digitally analyse the features. This study aims to correlate novel features including necrosis, degree of cellular atypia and number of mitoses (proliferating cells with clinical stage of disease at presentation and outcome (disease relapse, tumour spread or death in testicular germ cell tumour cases managed by the Oxford (Thames Valley Cancer Network) Supraregional Germ Cell MDT. The study will examine retrospective and prospective cases.
REC name
London - Westminster Research Ethics Committee
REC reference
14/LO/2074
Date of REC Opinion
14 Nov 2014
REC opinion
Favourable Opinion