HIS Alternative II - V1.0
Research type
Research Study
Full title
HIS Alternative II : A Randomised Trial of His Pacing Versus Biventricular Pacing in Symptomatic HF Patients With Left Bundle Branch Block – A Multicentre Randomised Controlled Trial
IRAS ID
235999
Contact name
Daniel Keene
Contact email
Sponsor organisation
Imperial College Healthcare NHS Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Cardiac pacing is the treatment of choice for managing patients with bradycardia. Although right ventricular apical pacing is the standard therapy, it is associated with an increased risk of pacing-induced cardiomyopathy and heart failure. Physiological pacing using His bundle pacing and left bundle branch pacing has recently evolved as the preferred alternative pacing option.
The study will show the feasibility of using direct HIS pacing or Left bundle branch pacing (LBB pacing) as an alternative to biventricular pacing in patients with symptomatic heart failure and an ECG with a typical left bundle branch block.
The study's primary endpoint is the echocardiographic response after six months, defined as a relative decrease in left ventricular systolic diameter relative to baseline in a group of patients with conduction disease and heart failure.
If the study shows that direct HIS pacing or LBB pacing is a possible alternative to biventricular pacing, it may provide evidence alongside other research that could change international guidelines.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
22/LO/0837
Date of REC Opinion
20 Feb 2023
REC opinion
Further Information Favourable Opinion