HIPPO

• Research type

  Research Study

• Full title

  Hospital-acquired Infection Prevention with Parenteral Omegaven

• IRAS ID

  1008285

• Contact name

  Zudin Puthucheary

• Contact email

  z.puthucheary@qmul.ac.uk

• Sponsor organisation

  Queen Mary University of London

• ISRCTN Number

  ISRCTN11451475

• Research summary

  Background and study aims:
  Patients admitted to critical care unit often end up having new infections while they are in hospital, which can be very serious. Omega-3 fatty acids, which are fish oil extracts, may be helpful in reducing the number of people that have new infections and possibly, reduce the
  length of hospital stay. However, we need to find the correct dose that can be given to these patients. This study will help us establish a dose that can be given to similar patients in future and build a case for future studies.

  Who can participate?
  Patients admitted to the Intensive Care Unit.

  What does the study involve?
  Participants will receive either omega-3 fatty acids for 10 days, or standard care (no extra treatments)

  What are the possible benefits and risks of participating?
  Risks: We are not expecting any serious side effects to occur during this study. Omegaven has fish oil, is a licensed drug in the EU, and has
  been used safely in other groups, e.g. healthy people, people with liver problems, children etc. Some patients have experienced vomiting or
  had a rash.

  Benefits: We cannot promise that there will be benefits, but we are trying to understand if giving patients Omegaven prevents them getting serious infections while in hospital.

  Where is the study run from?
  The study will be conducted at The Royal London Hospital, part of Barts Health NHS Trust.

  When is the study starting and how long is it expected to run for?
  The study starts in January 2025 and is expected to run for 1 year until January 2026.

  Who is funding the study?
  The funder for this trial is Fresenius Kabi.

  Who is the main contact?
  Prof Zudin Puthucheary
  Professor of Intensive Care Medicine
  z.puthucheary@qmul.ac.uk

• REC name

  London - Fulham Research Ethics Committee

• REC reference

  24/LO/0914

• Date of REC Opinion

  20 Feb 2025

• REC opinion

  Further Information Favourable Opinion