Hip Osteoarthritis treatment using Autologous Stem cell Therapy (HOAST
Research type
Research Study
Full title
Hip Osteoarthritis treatment using Autologous Stem cell Therapy (HOAST)
IRAS ID
195788
Contact name
Alice Harin
Contact email
Sponsor organisation
Oxford University
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
We aim to investigate whether the use of stem cells taken from a patients own body for the treatment of early osteoarthritis of the hip is superior to current surgical treatment options by way of a randomized controlled trial comparing the two.
Previously, the only way to surgically treat hip OA was with a joint replacement, but more and more research is being undertaken to find new ways to treat osteoarthritis earlier on in a less invasive manner, to reduce the morbidity and cost associated with the treatment of osteoarthritis. Currently, our best surgical treatment (best chondral therapy for early OA is with hip arthroscopy (key hole surgery) and microfracture, where small holes are drilled into the damaged cartilage of the hip joint to promote bleeding and scar tissue formation to form a new joint surface. We want to see if the use of stem cells, taken from a patients bone marrow in their hip at the time of surgery and then applied to the damaged cartilage surface via key hole surgery, along with microfracture, gives better results than just microfracture alone.
We will be performing a smaller pilot study in order to determine the size of a full follow up study based on the results we get. This pilot will involve 40 patients, with half randomized to each treatment option (best chondral therapy vs stem cell therapy plus best chondral therapy). The patients will be adults aged 18-75 years with early osteoarthritis and no prior medical hip issues. These will be patients who were already planning on having best chondral therapy.
The study will take place over 2 sites, The Nuffield Orthopaedic Centre and The Manor Hospital in Oxford. We predict the pilot phase of the study to take 1 year and the follow up study to take 2 years to complete.
REC name
South Central - Oxford B Research Ethics Committee
REC reference
16/SC/0311
Date of REC Opinion
2 Aug 2016
REC opinion
Further Information Favourable Opinion