High vs low flow nasal O2 for acute hypercapnic respiratory failure
Research type
Research Study
Full title
High flow nasal cannula therapy for initial oxygen administration in acute hypercapnic respiratory failure – a comparison study of two current standards of care
IRAS ID
272125
Contact name
Murali Shyamsundar
Contact email
Sponsor organisation
Belfast Health and Social Care Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 7 months, 1 days
Research summary
Chronic lung conditions such as smoking related lung damage lead to breathing failure. This results in accumulation of gases such as carbon-di-oxide in the body especially during periods of illness known as exacerbations.
Current management of carbon-di-oxide accumulation is administration of oxygen, nebulisers, antibiotics etc and if necessary, provide a tight fitting mask around the face to provide breathing support. If this fails, then a patient is placed on a mechanical ventilator. The tight fitting mask therapy is also called non-invasive ventilation and is used widely but patients acceptability of the therapy is limited.
Providing a high flow of air with some oxygen could potentially provide the same benefit of the non-invasive ventilation and may also be better accepted by patients.
Currently the knowledge and evidence from studies suggest a beneficial role for this high flow therapy but this has not been investigated in well designed studies.
In the proposed study we aim to investigate whether use of the high flow therapy reduces the need for non-invasive ventilation in patients who present with a recent onset accumulation of carbon-di-oxide in their body due to long-term lung disease. If this shows benefit, it will lead to a bigger trial with patient benefitting by reduction in the non-invasive ventilation or indeed a need for an invasive breathing machine.
REC name
HSC REC A
REC reference
20/NI/0049
Date of REC Opinion
1 May 2020
REC opinion
Further Information Favourable Opinion