High risk lung health clinic
Research type
Research Study
Full title
Implementation of a lung health clinic in high-risk individuals in South East London: A prospective feasibility cohort study
IRAS ID
212312
Contact name
Arjun Nair
Contact email
Sponsor organisation
Guy's & St Thomas' Foundation NHS Trust
Duration of Study in the UK
1 years, 8 months, 1 days
Research summary
Lung cancer is the second most common cancer amongst men and women, after prostate cancer and breast cancer, respectively. Cigarette smoke remains the greatest causative agent and is the main cause in approximately 90% of patients.
Survival rates for lung cancer are dependent on the stage of lung cancer at the time of diagnosis. Patients who experience symptoms of lung cancer are often identified with lung cancer in the late stages, where surgery for curative intent is less likely (Kauczor, 2015). The symptoms associated with the identification of lung cancer are often non-specific, making clinical decisions to suspect lung cancer difficult. Identification of lung cancer in patients who are symptom-free could improve early stage diagnosis and decrease mortality, however studies have shown that uptake to lung screening studies has been poor.
The UK Lung Screen (UKLS) trial is the only feasibility screening trial to take place in the UK to date. Patients were initially invited to complete a lung cancer risk questionnaire; those considered at high risk were then contacted to assess their interest in joining the study before being randomised to either the low-dose CT screening or control arms. Of the 247,354 patients approached, 2,028 were randomised to the CT arm (1,994 underwent low dose CT [LDCT]) of which only 42 (2.1%) of patients were identified with lung cancer.
This study, a one-site non-randomised, non-blinded prospective feasibility study aims to assess the uptake of low-dose computed tomography (a scan that uses radiation to produce images of the body in slices) when offered as part of the lung health clinical assessment. Primary care patients who are current or former smokers (smoking cessation <15 years) and aged between 55-80 will be invited to complete a short questionnaire to assess their lung cancer risk and consequently, their need to attend a lung health clinic.
REC name
London - London Bridge Research Ethics Committee
REC reference
17/LO/0442
Date of REC Opinion
18 Apr 2017
REC opinion
Further Information Favourable Opinion