High Resolution Retinal Imaging
Research type
Research Study
Full title
High resolution fundus autofluorescence, fluorescein angiography and indocyanine green angiography
IRAS ID
216263
Contact name
Adnan Tufail
Contact email
Sponsor organisation
Moorfields Eye Hospital NHS Foundation Trust
Clinicaltrials.gov Identifier
TBC, NCT
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
1. The aim of this exploratory study is to provide proof-of-concept to see if very high resolution fundus angiography is feasible using a modified version of the current imaging system. This will enable potential novel insights into retinal and choroidal disease of the eye and as a potential endpoint for future clinical studies. We anticipate it's application across a broad range of retinal disorders including age related macular degeneration and diabetic eye disease for example. Currently the only other method of taking high resolution imaging requires the use of an adaptive optics system, which is not only expensive, time consuming but so far, used only in experimental settings. The machine used in our proposed study is a modification of the current clinically used technique and has the potential to be more widely available with a familiar interface and information provided in real time.
2. The modification is to the optics of an existing CE marked imaging machine but with added reduced scan angle to better focus and detect the reflected images.
3. Patients who require angiography as part of their routine clinical care will be eligible to take part.
4. This is a single site study at the Moorfields Eye Hospital
5. This will only entail one single visit. Images will be obtained on the standard angiography machine as per their normal clinical care and the modified high resolution version will be imaged at the same visit. No additional dye injection or additional invasive procedures will be required.
REC name
London - Riverside Research Ethics Committee
REC reference
16/LO/2083
Date of REC Opinion
11 Nov 2016
REC opinion
Favourable Opinion