Hi Flo
Research type
Research Study
Full title
Evaluating the feasibility and safety of using nasal high flow oxygen for five days postoperatively to reduce respiratory complications after oesophagectomy for cancer
IRAS ID
219785
Contact name
George Bouras
Contact email
Sponsor organisation
University Hospitals North Midlands NHS Trust
Duration of Study in the UK
1 years, 5 months, 30 days
Research summary
A significant proportion of patients (20%) have breathing complications following oesophagectomy. Applying positive pressure through the mouth to support breathing is not recommended due to risks related to swallowing air. High flow oxygen delivered through nasal tubes is an alternative approach. Nasal cannulae achieve similar results when compared to oral high pressure support in cardiac surgery. The use of nasal high flow in patients undergoing oesophagectomy is a novel technique that has not been previously studied.
Nasal high flow will be delivered postoperatively to patients undergoing oesophagectomy in a tertiary cancer referral centre. This single-centre cohort study will evaluate the safety of using nasal high flow in oesophagectomy patients. Physiological parameters, adverse events and clinical outcome will be recorded in consecutive patients undergoing oesophagogastric surgery over a twelve-month period.
This study will challenge the hypothesis that the use of nasal high-flow will lower the rates of breathing complications such as pneumonia thereby reducing the demands on intensive care, shortening hospital stay and improving patient quality of life. The results will inform the design of a larger multicentre clinical trial comparing nasal high flow to conventional methods by facilitating sample size calculation.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
18/WM/0054
Date of REC Opinion
4 Jun 2018
REC opinion
Further Information Favourable Opinion