Hereditary bleeding disorders & placental syndrome.
Research type
Research Study
Full title
Are women with hereditary bleeding disorders protected against placental syndrome events? A retrospective cohort study.
IRAS ID
228933
Contact name
Rezan Abdul-Kadir
Contact email
Sponsor organisation
Royal Free London NHS FoundationTrust
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
We would like to find out whether women with certain inherited bleeding disorders are less likely to develop placental syndrome events in pregnancy. This will help us to understand more about this disease.
Placental syndrome includes different medical problems in pregnancy, such as pre-eclampsia (when the blood pressure is high and protein is detected in the urine), abruption (when the placenta separates prematurely), growth restriction (when a baby is small or does not grow as it should) and stillbirth. It is also associated with preterm birth, whether caused by medical intervention or if spontaneous.
We have a Haemophilia Centre on-site who specialise in bleeding disorders. We would like to look back at these rare adult patients who have passed through our care in their pregnancies in the last 15 years to see whether these patients had placental syndrome events or not. We estimate that there will be 300 patients.
We will be comparing these to 1000 patients from the general population at the same hospital who are unaffected by bleeding disorders, so that we may compare the prevalence of this condition.
REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
19/YH/0063
Date of REC Opinion
7 Mar 2019
REC opinion
Favourable Opinion