Hemodynamics in repaired type A aortic dissection
Research type
Research Study
Full title
Computational fluid dynamics in predicting progressive aortic dilatation following type A aortic dissection surgical repair
IRAS ID
281613
Contact name
Saeed Mirsadraee
Contact email
Sponsor organisation
R&D, Royal Brompton Hospital
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Supra-commissural replacement of the ascending aorta with a synthetic graft is the established surgical technique for the treatment of type A aortic dissection. Following repair, a subset of patients are at risk of aortic rupture due to further dilatation of the residual dissected aorta. Currently there is no reliable clinical means to predict the risk of aneurysmal dilatation and serial imaging is used to detect interval size changes. This study aims to examine if computational fluid dynamics simulations could identify progressive aortic dilatation in type A aortic dissection patients following surgical repair and help understanding the underlying mechanisms.
Computational fluid dynamics is an alternative approach that allows detailed assessment of flow patterns and estimation of wall shear stress and pressure within blood vessels, and therefore has been applied increasingly to gain better insights into the hemodynamics in cardiovascular diseases
Using the validated database of patients at Royal Brompton and Harefield hospitals, patients with progressive aortic dilatation will be compared with patients with stable aortic diameters. Three-dimensional patient-specific dissection geometries are reconstructed from post-dissection repair computed tomography angiography images. The geometries will then couple with physiological boundary conditions to produce clinically relevant results. Geometric and hemodynamic parameters will be assessed. Statistical analysis will be carried out to determine significant differences between the two groups.REC name
West Midlands - Solihull Research Ethics Committee
REC reference
20/WM/0145
Date of REC Opinion
4 May 2020
REC opinion
Favourable Opinion