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Hemodynamics in repaired type A aortic dissection

  • Research type

    Research Study

  • Full title

    Computational fluid dynamics in predicting progressive aortic dilatation following type A aortic dissection surgical repair

  • IRAS ID

    281613

  • Contact name

    Saeed Mirsadraee

  • Contact email

    s.mirsadraee@rbht.nhs.uk

  • Sponsor organisation

    R&D, Royal Brompton Hospital

  • Duration of Study in the UK

    2 years, 0 months, 1 days

  • Research summary

    Supra-commissural replacement of the ascending aorta with a synthetic graft is the established surgical technique for the treatment of type A aortic dissection. Following repair, a subset of patients are at risk of aortic rupture due to further dilatation of the residual dissected aorta. Currently there is no reliable clinical means to predict the risk of aneurysmal dilatation and serial imaging is used to detect interval size changes. This study aims to examine if computational fluid dynamics simulations could identify progressive aortic dilatation in type A aortic dissection patients following surgical repair and help understanding the underlying mechanisms.
    Computational fluid dynamics is an alternative approach that allows detailed assessment of flow patterns and estimation of wall shear stress and pressure within blood vessels, and therefore has been applied increasingly to gain better insights into the hemodynamics in cardiovascular diseases
    Using the validated database of patients at Royal Brompton and Harefield hospitals, patients with progressive aortic dilatation will be compared with patients with stable aortic diameters. Three-dimensional patient-specific dissection geometries are reconstructed from post-dissection repair computed tomography angiography images. The geometries will then couple with physiological boundary conditions to produce clinically relevant results. Geometric and hemodynamic parameters will be assessed. Statistical analysis will be carried out to determine significant differences between the two groups.

  • REC name

    West Midlands - Solihull Research Ethics Committee

  • REC reference

    20/WM/0145

  • Date of REC Opinion

    4 May 2020

  • REC opinion

    Favourable Opinion