Heartbeat Matrix Pilot
Research type
Research Study
Full title
Heartbeat Matrix Pilot: Accelerating targeted treatments for patients with inherited heart diseases.
IRAS ID
269251
Contact name
Paulus Kirchhof
Contact email
Sponsor organisation
Head of Research Governance and Integrity
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Inherited heart diseases take the lives of thousands of young patients and severely affects the lives of their entire families through sudden death and heart failure. Our current treatments, including defibrillators and heart transplantation, are blunt instruments that mainly target late and severe consequences of these inherited diseases. Treatments that target the key biological drivers of these diseases are needed to help patients with inherited heart diseases.
Research into the genetic basis of inherited heart diseases suggests an overarching genomic paradigm shaped by defects in genes that are critical for cardiac cell function. Therefore the Heartbeat Matrix Pilot Study will utilise whole genome sequencing to investigate the common gene variants associated with cardiovascular disease in 4,000 genomes to create a complete genomic map of inherited heart diseases.
We expect to include ca. 2,000 patient samples from the HBRC, including those which have consented from RATE-AF (160) and BBC-AF (ca. 1,500) in addition to new samples obtained from the HBRC (ca 340). The study will also include 2,000 patient data sets which have previously been collected and consented by deCODE. This study will enable the Heartbeat Matrix to robustly test and deliver effective new therapies and concepts to cure inherited heart diseases in an accelerated, sustainable innovation platform for patients.REC name
London - West London & GTAC Research Ethics Committee
REC reference
20/LO/0184
Date of REC Opinion
14 Feb 2020
REC opinion
Favourable Opinion