Health-related quality of life (HRQoL) in patients receiving OPAT
Research type
Research Study
Full title
Evaluation of health-related quality of life (HRQoL) in patients receiving outpatient parenteral antimicrobial therapy (OPAT)
IRAS ID
316619
Contact name
Oyewole Chris Durojaiye
Contact email
Sponsor organisation
University Hospitals of Derby and Burton NHS Foundation Trust
Duration of Study in the UK
1 years, 1 months, 1 days
Research summary
Outpatient parenteral antimicrobial therapy (OPAT) has been shown to be safe, clinically efficacious and acceptable for treating a wide range of infections with high levels of patient satisfaction and substantial cost savings. However, the impact of OPAT on health-related quality of life (HRQoL) is not well understood. HRQoL, an important component of patient-centred care, is a multi-dimensional concept commonly used to examine the impact of health status on quality of life. The National Institute for Health and Care Excellence (NICE) has recommended the EQ-5D as the preferred measure of HRQoL in adults in the UK.
An understanding of the HRQoL in patients receiving OPAT would support improved patient selection and contribute to optimising the patient experience of OPAT. To the best of our knowledge, no study has assessed the HRQoL of patients treated through OPAT within the NHS setting.
The study will measure changes and identify predictors of change of HRQoL (using EQ-5D) in patients treated through OPAT at The University Hospitals of Derby and Burton (UHDB) NHS Foundation Trust, and evaluate the association between HRQoL and OPAT outcomes.
Summary of Results
Patients receiving outpatient parenteral antimicrobial therapy (OPAT) generally have a lower quality of life compared to the general population. This can be attributable not only to the need for OPAT but also to the presence of underlying comorbidities.OPAT is associated with improvements in patient-reported quality of life measures and facilitates an early return to work or school. Consequently, it can contribute to financial stability, job security, and prevent interruptions in career advancement and educational attainment.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
22/NW/0299
Date of REC Opinion
30 Aug 2022
REC opinion
Further Information Favourable Opinion