HD-SAGA
Research type
Research Study
Full title
High Density Scar Guided Atrial Fibrillation Mapping (HD-SAGA)
IRAS ID
231918
Contact name
Waqas Ullah
Contact email
Sponsor organisation
University Hospital Southampton NHS Foundation Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
There is increasing evidence that having Atrial Fibrillation (AF) is associated with scarring of the upper chamber of the heart, the left atrium (LA). Rapid high density mapping equipment has now become available with the capability of defining the electrical scar in the atrium in detail. The equipment used to do this is standard approved equipment for the procedure but its use for making scar maps has not been fully assessed. In this study therefore we are aiming to collect high density scar maps in AF and normal rhythm to see how they compare. We are going to collect the maps in different ways to see if that changes their accuracy. We are also going to see if the values which people have previously suggested as representing scar with lower density mapping systems are still appropriate where high density mapping equipment is used. The results from this study will help to improve our understanding of scar in the atrium and help to show us the most efficient way to collect scar information using this high density mapping equipment. In the future we may be able to use these very detailed scar maps to tailor and refine the way we ablate patients with AF, though the focus of the current study is just on collecting the scar information. The second part of the study will look at how we ablate patients. The challenge for clinicians is that we are applying energy to affect the tissues without having an accurate way to assess this effect for an individual ablation. Localised impedance measurement has now become incorporated into our standard equipment. We would aim to measure this during ablation to get an idea of how this is affected during energy delivery. This may help us understand and use this technology to guide ablation.
REC name
South Central - Oxford A Research Ethics Committee
REC reference
18/SC/0077
Date of REC Opinion
8 Mar 2018
REC opinion
Further Information Favourable Opinion