HCN channel function in human tissue
Research type
Research Study
Full title
An investigation into voltage gated ion channel function in human tissue
IRAS ID
196602
Contact name
Christopher E G Moore
Contact email
Sponsor organisation
Portsmouth Hospital NHS Trust R&D department
Duration of Study in the UK
1 years, 1 months, 0 days
Research summary
The study aims to gain insight into the function of ion channels known as HCN channels in human brain and nerve tissue. HCN channel function has been well studied in animals and in cells from the human heart but human brain and nerve tissue has not. There is evidence from animal studies that poor HCN function in the brain can lead to epilepsy but this has not been shown in humans. Also excess HCN function has been shown in humans with restless leg syndrome; the biological properties of human peripheral nerve HCN function are unknown. Understanding HCN activity in human tissues may give information about how to modulate function and treat related diseases.
REC name
South Central - Hampshire B Research Ethics Committee
REC reference
16/SC/0082
Date of REC Opinion
22 Mar 2016
REC opinion
Further Information Favourable Opinion