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Haemostatic markers in ECMO (HAE) study

  • Research type

    Research Study

  • Full title

    Prospective cohort study of haemostatic activation markers and correlation with bleeding and thrombotic complications in patients receiving extracorporeal membrane oxygenation(ECMO)

  • IRAS ID

    235036

  • Contact name

    Deepa Jayakody Arachchillage

  • Contact email

    d.arachchillage@rbht.nhs.uk

  • Sponsor organisation

    Royal Brompton and Harefield NHS Foundation Trust

  • Duration of Study in the UK

    3 years, 0 months, 0 days

  • Research summary

    Extracorporeal membrane oxygenation (ECMO) and ventricular assist devices (VAD) are techniques increasingly used to provide support to patients with severe refractory cardiac and respiratory failure. Despite increasing experience with ECMO and VAD recent technical improvements, bleeding and clotting complications are now a leading cause of morbidity and mortality in these patients. Intracranial haemorrhage (ICH) has been reported with an incidence ranging from 5% up to 19%, with a predominantly fatal outcome. \nWe do not fully understand why these problems are so common although there are many possible factors, including the fact that these patients are already very ill and that anti-coagulant drugs are needed to stop blockage of the blood circuits. \nIn this study we propose simply to measure a number of aspects of blood clotting in patients undergoing ECMO whilst at the same time closely monitoring them bleeding and thrombotic complications \nOur rationale is that better definition of the changes in coagulation parameters and their relation to bleeding mainly intracranial haemorrhage (ICH) and thrombosis will allow us to formulate better protocols for managing these patients. Based on our study findings, a large multicentre prospective study will be designed to assess the benefit of early interventions based on our measurements to reduce the risk of ICH as well as other bleeding and thrombotic complications in patients receiving mechanical circulatory or ventilator support with ECMO or VAD.\n

  • REC name

    London - South East Research Ethics Committee

  • REC reference

    18/LO/0183

  • Date of REC Opinion

    8 May 2018

  • REC opinion

    Further Information Favourable Opinion