Haemophilia kids rearfoot motion study
Research type
Research Study
Full title
The Vigilance Project (Translating a predictive model for the presence of ankle joint disease into prospective screening and surveillance tools) Study 2: Rear Foot Motor Control in Children with Haemophilia
IRAS ID
243426
Contact name
Ann McCarthy
Contact email
Sponsor organisation
Royal Free London NHS Foundation Trust
Duration of Study in the UK
1 years, 6 months, 28 days
Research summary
Haemophilia is a disorder of blood clotting mechanisms almost wholly affecting male children that can cause bleeds to occur inside joints ultimately leading to joint degeneration. This does not happen with all haemophiliacs and is part dependent on how severely they are affected by the condition, but is not wholly explained by the history of bleeding into the joints and it is thought that the onset of degeneration is multifactorial. At present the most commonly affected joint is the ankle. Previous studies have suggested that musculoskeletal factors may influence the onset of joint disease in haemophilia. This study will examine an aspect of this not previously investigated: control of the rear part of the foot in walking and other tasks. Three groups of children fifteen aged between 7 and 11 years will be asked to participate in a case control study. This will include children who have experienced bleeds into their ankle joints, haemophiliacs with no history of bleeding and typically developing peers. Comparison will be made between the groups with the aim of identifying discrepancies in movement control. This will be achieved in human movement laboratory environment using motion capture systems and force plate data. Ultrasound examination of the ankle joint will establish the health of the joint. It is hoped that we will then be able to develop interventions such as exercise programmes to limit the impact of any significant factors found on joint disease initiation and/or progression.
Please note that throughout all documents relating to this study, the words boys and children will be used interchangeably and at no point does the word children refer to a girl.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
18/WM/0342
Date of REC Opinion
10 Dec 2018
REC opinion
Further Information Favourable Opinion