Haemodynamics of Mitral Regurgitation Reduction

  • Research type

    Research Study

  • Full title

    Comparative STudy chaRacterising the physiological changEs induced by Surgical and tranScatheter Mitral Regurgitation reduction - STRESS-MR



  • Contact name

    Simon Redwood

  • Contact email


  • Sponsor organisation

    King's College London

  • Duration of Study in the UK

    2 years, 11 months, 28 days

  • Research summary

    Mitral valve leak, or mitral regurgitation (MR) is the commonest heart valve disease in the developed world affecting one in five people. If left untreated without surgery, severe MR leads to heart failure hospitalisation and death, yet half of patients are considered to be at high surgical risk. The way the heart reacts to mitral valve surgery is complex with high rates of prolonged hospital stay and mortality, allegedly in part due to sudden increases in the pressure load on the heart resulting from MR eradication. Despite this, there are no contemporary studies investigating the early changes in heart function and pressure. Less invasive key hole techniques have advanced the treatment of MR in those considered high surgical risk with lower morbidity and mortality. We are currently uncertain regarding which treatment option results in more favourable heart pump performance.
    We aim to compare the short and medium-term impact of complete versus incomplete reduction of MR through evaluation of heart pump performance, wall stress and change in heart size. This will enhance our understanding of changes induced by eradication of MR thus informing future clinical trials with a view to patient-specific tailoring of MR treatment strategies to improve outcomes and survival.

  • REC name

    Wales REC 1

  • REC reference


  • Date of REC Opinion

    22 Apr 2022

  • REC opinion

    Further Information Favourable Opinion

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