HaemodYnamic AssesmEnt in KidNey Replacement TherApy (Hyena)
Research type
Research Study
Full title
HaemodYnamic AssesmEnt in KidNey Replacement TherApy (Hyena)
IRAS ID
301921
Contact name
Lui Forni
Contact email
Sponsor organisation
Royal Surrey Hospital NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Critically ill patients on intensive care often suffer from acute kidney injury (AKI) manifest as a rapid reduction in kidney function. Where severe this will require treatment with kidney replacement therapy (KRT) which includes intermittent treatments such as intermittent haemodialysis (HD) or continuous therapies including continuous veno-venous haemodialfiltration (CVVHD) the latter often performed in the intensive care unit (ICU). Recent work has investigated patients with AKI and found detrimental changes in heart function when undergoing IHD, as seen on an ultrasound of the heart (echocardiogram) using strain analysis to investigate in detail regions of the heart wall. It is not known whether patients with AKI who undergo continuous therapies will develop the same changes in heart function. Furthermore, little is known about changes in other aspects of cardiac function including cardiac output and other physiological parameters.
This study aims to recruit patients in the ICU who require KRT. Baseline heart function will be measured non-invasively using echocardiography and using a bioreactance monitor, which uses electrodes like an ECG machine, which measures other heart function parameters such as the cardiac output. Follow up echocardiography will occur during KRT and then again following cessation of KRT. Common, routinely-measured, physiological parameters including blood pressure (BP) and cardiac output (CO) will also be measured. This should allow investigation as to possible factors involved in any cardiac dysfunction which may (or may not) be seen.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
22/LO/0193
Date of REC Opinion
22 Sep 2022
REC opinion
Further Information Favourable Opinion